Axon Guidance: Robos Make the Rules

Curr Biol. 2001 Apr 17;11(8):R300-3. doi: 10.1016/s0960-9822(01)00169-5.

Abstract

A central feature of the developing nervous system is the midline region, which guides growing axons with both short- and long-range signals. New research shows that a trio of receptors, the Robos, are crucial in allowing axons to interpret these signals, ensuring correct route-finding within the emerging axon scaffold.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Drosophila Proteins*
  • Insect Proteins / genetics
  • Insect Proteins / metabolism
  • Insect Proteins / physiology*
  • Ligands
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Nerve Tissue Proteins / physiology*
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / metabolism
  • Receptors, Immunologic / physiology*

Substances

  • Drosophila Proteins
  • Insect Proteins
  • Ligands
  • Nerve Tissue Proteins
  • Receptors, Immunologic
  • Robo2 protein, Drosophila
  • robo3 protein, Drosophila
  • roundabout protein
  • sli protein, Drosophila