Human disease: calcium signaling in polycystic kidney disease

Curr Biol. 2001 May 1;11(9):R356-60. doi: 10.1016/s0960-9822(01)00193-2.


Polycystic kidney disease results from loss of function of either of two novel proteins, polycystin-1 or polycystin-2. Recent studies show that intracellular calcium signaling is important in kidney development, and define defects in this signaling pathway as the basis of cyst formation in polycystic kidney disease.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium Channels / physiology
  • Calcium Signaling*
  • Humans
  • Membrane Proteins / physiology
  • Polycystic Kidney Diseases / metabolism*
  • Proteins / physiology
  • TRPP Cation Channels


  • Calcium Channels
  • Membrane Proteins
  • Proteins
  • TRPP Cation Channels
  • polycystic kidney disease 1 protein
  • polycystic kidney disease 2 protein