Oxidative stress, human genetic variation, and disease

Arch Biochem Biophys. 2001 May 1;389(1):84-93. doi: 10.1006/abbi.2001.2295.

Abstract

Oxidative stress has been implicated in numerous pathophysiological conditions and also aging. The tools for studying oxidative stress are now expanding as a result of the human genome effort and, in particular, expanding knowledge on human genetic variation. A few genetic variants, mostly in the form of single nucleotide polymorphisms of relevance to oxidative stress are already studied by a molecular epidemiologic approach. A review of the current knowledge on variant human genes that are directly implicated in human protection against oxidative stress is presented.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antioxidants
  • Cardiovascular Diseases / genetics
  • Genetic Predisposition to Disease*
  • Genetic Variation*
  • Glutathione / metabolism
  • Glutathione Peroxidase / genetics
  • Glutathione Transferase / genetics
  • Humans
  • Isoenzymes / genetics
  • Mice
  • Microsomes / enzymology
  • Neoplasms / genetics
  • Oxidative Stress / genetics*
  • Parkinson Disease / genetics
  • Polymorphism, Single Nucleotide / genetics
  • Superoxide Dismutase / genetics

Substances

  • Antioxidants
  • Isoenzymes
  • glutathione peroxidase GPX1
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Glutathione Transferase
  • Glutathione