Abstract
Oxidative stress has been implicated in numerous pathophysiological conditions and also aging. The tools for studying oxidative stress are now expanding as a result of the human genome effort and, in particular, expanding knowledge on human genetic variation. A few genetic variants, mostly in the form of single nucleotide polymorphisms of relevance to oxidative stress are already studied by a molecular epidemiologic approach. A review of the current knowledge on variant human genes that are directly implicated in human protection against oxidative stress is presented.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antioxidants
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Cardiovascular Diseases / genetics
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Genetic Predisposition to Disease*
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Genetic Variation*
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Glutathione / metabolism
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Glutathione Peroxidase / genetics
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Glutathione Transferase / genetics
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Humans
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Isoenzymes / genetics
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Mice
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Microsomes / enzymology
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Neoplasms / genetics
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Oxidative Stress / genetics*
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Parkinson Disease / genetics
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Polymorphism, Single Nucleotide / genetics
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Superoxide Dismutase / genetics
Substances
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Antioxidants
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Isoenzymes
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glutathione peroxidase GPX1
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Glutathione Peroxidase
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Superoxide Dismutase
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Glutathione Transferase
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Glutathione