Marginal Zone and B1 B Cells Unite in the Early Response Against T-independent Blood-Borne Particulate Antigens

Immunity. 2001 May;14(5):617-29. doi: 10.1016/s1074-7613(01)00129-7.

Abstract

The rate of pathogen elimination determines the extent and consequences of an infection. In this context, the spleen with its highly specialized lymphoid compartments plays a central role in clearing blood-borne pathogens. Splenic marginal zone B cells (MZ), by virtue of their preactivated state and topographical location, join B1 B cells to generate a massive wave of IgM producing plasmablasts in the initial 3 days of a primary response to particulate bacterial antigens. Because of the intensity and rapidity of this response, combined with the types of antibodies produced, splenic MZ and B1 B cells endowed with a "natural memory" provide a bridge between the very early innate and the later appearing adaptive immune response.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens, Bacterial / immunology*
  • B-Lymphocytes / immunology*
  • Cells, Cultured
  • Immunophenotyping
  • Lipopolysaccharides / immunology
  • Membrane Glycoproteins / biosynthesis
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Proteoglycans / biosynthesis
  • Receptors, Complement 3d / immunology*
  • Spleen / cytology
  • Spleen / immunology*
  • Streptococcus pneumoniae / immunology*
  • Syndecans
  • T-Lymphocytes / immunology*

Substances

  • Antigens, Bacterial
  • Lipopolysaccharides
  • Membrane Glycoproteins
  • Proteoglycans
  • Receptors, Complement 3d
  • Syndecans