Effect of nebulized lidocaine on reactive airways

Am Rev Respir Dis. 1975 Jun;111(6):739-41. doi: 10.1164/arrd.1975.111.6.739.


Fourteen subjects with reversible obstructive lung disease inhaled one per cent lidocaine mist delivered by an ultrasonic nebulizer. The effect of ultrasonic nebulization per se was evaluated by a control study utilizing normal saline. After lidocaine inhalation there was a significant decrease in expiratory flow and an increase in airway resistance compared with either baseline or post-saline values. The changes were mild and do not preclude the continued use of nebulized lidocaine as an adjunct to bronchoscopy, but caution in its use is indicated.

MeSH terms

  • Adult
  • Aerosols
  • Airway Resistance / drug effects*
  • Bronchi / drug effects*
  • Bronchoscopy
  • Humans
  • Lidocaine / administration & dosage
  • Lidocaine / adverse effects
  • Lidocaine / pharmacology*
  • Lung Diseases, Obstructive / physiopathology*
  • Pulmonary Ventilation / drug effects*
  • Spirometry


  • Aerosols
  • Lidocaine