Daily and alternate-day corticosteroid regimens in treatment of giant cell arteritis: comparison in a prospective study

Ann Intern Med. 1975 May;82(5):613-8. doi: 10.7326/0003-4819-82-5-613.


Alternate-day corticosteroid therapy was compared with two daily corticosteroid regimens for the treatment of giant cell arteritis. In a prospective study 60 patients with this disease were randomly assigned to three treatment groups: group A, 15 mg of prednisone every 8 hours; group B, 45 mg of prednisone every morning; and group C, 90 mgof prednisone every other morning. After 1 month of treatment, the arteritis seemed to be completely suppressed in 18 patients in group A and 16 in group B but in only 6 in group C. In the 14 other patients in group C, the continuing symptoms were cyclic and developed during the day steroids were not given. By changing to a daily regimen, the arteritis was controlled in most patients in group C. Adverse reactions to prednisone were noted frequently in groups A and B but rarely in group C.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Biopsy
  • Female
  • Giant Cell Arteritis / drug therapy*
  • Giant Cell Arteritis / pathology
  • Humans
  • Male
  • Middle Aged
  • Prednisone / administration & dosage*
  • Prednisone / adverse effects
  • Prednisone / therapeutic use
  • Prospective Studies
  • Statistics as Topic
  • Temporal Arteries / pathology


  • Prednisone