Abstract
To enhance the stability in vivo, new derivatives of cytogenin were synthesized, and their biological activity and stability in mice were estimated. 2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propionic acid (NM-3) was found to be the most stable among them. It modified collagen-induced arthritis in mice. It also showed potent anti-angiogenic activity in a mouse dorsal air sac assay.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / metabolism
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Antibiotics, Antineoplastic / chemical synthesis*
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / metabolism
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Antibiotics, Antineoplastic / pharmacology*
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Arthritis / drug therapy
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Coumarins / chemical synthesis*
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Coumarins / chemistry
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Coumarins / metabolism
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Coumarins / pharmacology*
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Drug Stability
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In Vitro Techniques
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Isocoumarins
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Magnetic Resonance Spectroscopy
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Male
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Mice
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Mice, Inbred DBA
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Mice, Inbred ICR
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Neovascularization, Pathologic / drug therapy
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Rats
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Rats, Sprague-Dawley
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Spectrophotometry, Ultraviolet
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Spectroscopy, Fourier Transform Infrared
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antibiotics, Antineoplastic
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Coumarins
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Isocoumarins
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isocoumarin NM-3
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cytogenin