Histopathology of submandibular glands removed for sialolithiasis

Ann Otol Rhinol Laryngol. 2001 May;110(5 Pt 1):464-9. doi: 10.1177/000348940111000513.


We reviewed the clinical history of 48 consecutive patients who underwent submandibular gland removal for radiologically proven sialolithiasis. The specimens were examined by a pathologist blinded to the clinical data. A histopathologic classification into I of 3 grades was established by evaluating the degrees of atrophy, fibrosis, and inflammation. A correlation between the clinical and pathological variables was sought in order to define clinical variables that would predict abnormal submandibular glands that required extirpation. A significant percentage of the submandibular glands exhibited normal histologic findings. The patients with normal submandibular glands had a clinical evolution similar to that of other patients with severely damaged glands. The only clinical variable that correlated with increased histopathologic alteration was the patient's age. In view of the newly available diagnostic and therapeutic techniques for sialolithiasis, a conservative attitude to submandibular gland resection appears justified.

MeSH terms

  • Adult
  • Analysis of Variance
  • Female
  • Humans
  • Male
  • Salivary Gland Calculi / pathology*
  • Salivary Gland Calculi / surgery
  • Submandibular Gland Diseases / pathology*
  • Submandibular Gland Diseases / surgery