Transcriptional regulation of matrix gla protein

Z Kardiol. 2001;90 Suppl 3:38-42. doi: 10.1007/s003920170040.

Abstract

Matrix Gla Protein (MGP) is a small protein which is thought to be an inhibitor of tissue calcification and a regulator of cell differentiation. In this study we have examined the transcriptional regulation of MGP within rat vascular smooth muscle cells (VSMCs). We found that MGP transcription is downregulated by retinoic acid and transforming growth factor beta (TGF beta) whereas it is upregulated by vitamin D3 and cyclic AMP.

MeSH terms

  • Animals
  • Arteriosclerosis / genetics*
  • Calcinosis / genetics*
  • Calcium-Binding Proteins / genetics*
  • Cholecalciferol / pharmacology
  • Cyclic AMP / pharmacology
  • Down-Regulation / drug effects
  • Extracellular Matrix Proteins*
  • Gene Expression Regulation / drug effects
  • Humans
  • Muscle, Smooth, Vascular / drug effects
  • Rats
  • Transcription, Genetic / genetics*
  • Transforming Growth Factor beta / pharmacology
  • Tretinoin / pharmacology
  • Up-Regulation / drug effects

Substances

  • Calcium-Binding Proteins
  • Extracellular Matrix Proteins
  • Transforming Growth Factor beta
  • matrix Gla protein
  • Cholecalciferol
  • Tretinoin
  • Cyclic AMP