A prospective evaluation of health-related quality of life after ileal pouch anal anastomosis for ulcerative colitis

Am J Gastroenterol. 2001 May;96(5):1480-5. doi: 10.1111/j.1572-0241.2001.03801.x.


Objectives: The ileal pouch anal anastomosis is a safe and effective procedure but is also associated with pouchitis, small bowel obstruction, and incontinence. We prospectively evaluated the health-related quality of life using generic and disease-specific measures in a cohort of patients with ulcerative colitis undergoing ileal pouch anal anastomosis.

Methods: Health-related quality of life measures included the Time Trade-off, Rating Form of IBD Patient Concerns, and the Short-Form 36. Assessments occurred preoperatively and 1, 6, and 12 months postoperatively.

Results: Time Trade-off scores had significantly improved at the 1-month postoperative assessment and approached perfect health at the 12-month postoperative assessment. The Rating Form of IBD Patient Concerns revealed a significant reduction in patient concerns at 1 month, and this difference persisted at 6 and 12 months. Seven of the eight subscales of the Short-Form 36 revealed improved health-related quality of life postoperatively.

Conclusions: Health-related quality of life improved after ileal pouch anal anastomosis when assessed with both generic and disease-specific measures. Improvements were observed as early as 1 month postoperatively. These results may guide patients and physicians as they consider and prepare for the impact of ileal pouch anal anastomosis.

Publication types

  • Evaluation Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Colitis, Ulcerative / physiopathology*
  • Colitis, Ulcerative / surgery*
  • Female
  • Health Status*
  • Humans
  • Male
  • Middle Aged
  • Postoperative Period
  • Proctocolectomy, Restorative*
  • Prospective Studies
  • Quality of Life*
  • Time Factors