doi: 10.1021/np000441w.
Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships
Affiliations
- PMID: 11374978
- DOI: 10.1021/np000441w
Item in Clipboard
Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships
J Nat Prod.
2001 May.
Abstract
Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins. Among them, decursinol (1) represented the highest inhibitory activity toward AChE in vitro. The correlation of the inhibitory activities of the coumarins toward AChE with their chemical structures was studied.
Similar articles
-
Inhibition of acetylcholinesterase activity by essential oil from Citrus paradisi.Nat Prod Lett. 2001;15(3):205-10. doi: 10.1080/10575630108041281. Nat Prod Lett. 2001. PMID: 11858553
-
A New Coumarin from the Stems of Pterocarpus indicus.Nat Prod Commun. 2016 Sep;11(9):1287-1288. Nat Prod Commun. 2016. PMID: 30807024
-
Four new neuroprotective dihydropyranocoumarins from Angelica gigas.J Nat Prod. 2005 Jan;68(1):56-9. doi: 10.1021/np049705v. J Nat Prod. 2005. PMID: 15679317
-
A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease.Bioorg Med Chem. 2012 Feb 1;20(3):1175-80. doi: 10.1016/j.bmc.2011.12.042. Epub 2011 Dec 30. Bioorg Med Chem. 2012. PMID: 22257528 Review.
-
Structural and biogenetic relationships of isoflavonoids.Fortschr Chem Org Naturst. 1970;28:1-73. doi: 10.1007/978-3-7091-7123-3_1. Fortschr Chem Org Naturst. 1970. PMID: 4950979 Review. No abstract available.
Cited by
-
Natural Inhibitors of Cholinesterases: Chemistry, Structure-Activity and Methods of Their Analysis.Int J Mol Sci. 2023 Feb 1;24(3):2722. doi: 10.3390/ijms24032722. Int J Mol Sci. 2023. PMID: 36769043 Free PMC article. Review.
-
Natural products as sources of acetylcholinesterase inhibitors: Synthesis, biological activities, and molecular docking studies of osthole-based ester derivatives.Front Plant Sci. 2022 Nov 18;13:1054650. doi: 10.3389/fpls.2022.1054650. eCollection 2022. Front Plant Sci. 2022. PMID: 36466282 Free PMC article.
-
Plant Pyranocoumarins: Description, Biosynthesis, Application.Plants (Basel). 2022 Nov 16;11(22):3135. doi: 10.3390/plants11223135. Plants (Basel). 2022. PMID: 36432864 Free PMC article. Review.
-
Decursinol-mediated antinociception and anti-allodynia in acute and neuropathic pain models in male mice: Tolerance and receptor profiling.Front Pharmacol. 2022 Sep 29;13:968976. doi: 10.3389/fphar.2022.968976. eCollection 2022. Front Pharmacol. 2022. PMID: 36249788 Free PMC article.
-
Asymmetric organocatalyzed synthesis of coumarin derivatives.Beilstein J Org Chem. 2021 Aug 3;17:1952-1980. doi: 10.3762/bjoc.17.128. eCollection 2021. Beilstein J Org Chem. 2021. PMID: 34386105 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Chemical Information
