The genetics of fatty acid metabolism in Saccharomyces cerevisiae

Annu Rev Nutr. 2001;21:97-119. doi: 10.1146/annurev.nutr.21.1.97.

Abstract

Long-chain fatty acids are a vital metabolic energy source and are building blocks of membrane lipids. The yeast Saccharomyces cerevisiae is a valuable model system for elucidation of gene-function relationships in such eukaryotic processes as fatty acid metabolism. Yeast degrades fatty acids only in the peroxisome, and recently, genes encoding core and auxiliary enzymes of peroxisomal beta-oxidation have been identified. Mechanisms involved in fatty acid induction of gene expression have been described, and novel fatty acid-responsive genes have been discovered via yeast genome analysis. In addition, a number of genes essential for synthesis of the variety of fatty acids in yeast have been cloned. Advances in understanding such processes in S. cerevisiae will provide helpful insights to functional genomics approaches in more complex organisms.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biological Transport
  • Fatty Acids / blood
  • Fatty Acids / metabolism*
  • Fatty Acids / pharmacology
  • Gene Expression Regulation, Fungal / drug effects
  • Oxidation-Reduction
  • Peroxisomes / metabolism
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae / ultrastructure

Substances

  • Fatty Acids