Vitamin A, infection, and immune function

Annu Rev Nutr. 2001:21:167-92. doi: 10.1146/annurev.nutr.21.1.167.


In populations where vitamin A availability from food is low, infectious diseases can precipitate vitamin A deficiency by decreasing intake, decreasing absorption, and increasing excretion. Infectious diseases that induce the acute-phase response also impair the assessment of vitamin A status by transiently depressing serum retinol concentrations. Vitamin A deficiency impairs innate immunity by impeding normal regeneration of mucosal barriers damaged by infection, and by diminishing the function of neutrophils, macrophages, and natural killer cells. Vitamin A is also required for adaptive immunity and plays a role in the development of T both-helper (Th) cells and B-cells. In particular, vitamin A deficiency diminishes antibody-mediated responses directed by Th2 cells, although some aspects of Th1-mediated immunity are also diminished. These changes in mucosal epithelial regeneration and immune function presumably account for the increased mortality seen in vitamin A-deficient infants, young children, and pregnant women in many areas of the world today.

Publication types

  • Review

MeSH terms

  • Acute-Phase Reaction
  • Dietary Supplements
  • Humans
  • Immunity*
  • Infections* / immunology
  • Infections* / physiopathology
  • Nutritional Status
  • Vitamin A / administration & dosage
  • Vitamin A / physiology*
  • Vitamin A Deficiency / immunology


  • Vitamin A