IGF-I receptor signalling in transformation and differentiation

Mol Pathol. 2001 Jun;54(3):133-7. doi: 10.1136/mp.54.3.133.


The type 1 insulin-like growth factor receptor (IGF-IR) sends several signals, some of which are contradictory. When the concentrations of insulin receptor substrate 1 (IRS-1), a major substrate of the IGF-IR, are high, the signal is mitogenic, anti-apoptotic, and can even cause malignant transformation. However, in the absence of IRS-1, the IGF-IR sends a differentiation signal, which leads to granulocytic differentiation in haemopoietic cells. The mitogenic signal of the IGF-IR/IRS-1 combination depends largely, but not exclusively, on the activation of the phosphatidylinositol-3 kinase (PI3K).

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Biomarkers / analysis
  • Cell Differentiation / physiology*
  • Cell Transformation, Neoplastic*
  • Down-Regulation / physiology
  • Humans
  • Mice
  • Peroxidase / analysis
  • Phosphatidylinositol 3-Kinases / physiology
  • Receptor, IGF Type 1 / physiology*
  • Signal Transduction / physiology*


  • Biomarkers
  • Peroxidase
  • Phosphatidylinositol 3-Kinases
  • Receptor, IGF Type 1