Methadone tapering plus amantadine to detoxify heroin-dependent inpatients with or without an active cocaine use disorder: two randomised controlled trials

Drug Alcohol Depend. 2001 Jul 1;63(2):187-95. doi: 10.1016/s0376-8716(00)00206-4.


The efficacy of methadone tapering plus amantadine to detoxify heroin-dependent patients with or without an active cocaine use disorder was studied in a closed unit with two successive double-blind, placebo-controlled, 14-day trials. In the first trial, 40 heroin-dependent inpatients with an active cocaine use disorder were treated using methadone tapering, as well as amantadine (200-300 mg per day) or placebo. In the second trial, 40 heroin-dependent inpatients without an active cocaine use disorder received the same treatment. In both the trials, amantadine did not have a statistically significant effect on treatment completion, nor did it contribute, in completers, to a more rapid reduction in craving and opiate withdrawal. In the first trial, women were six times more likely than men to be non-completers, and on the last day of treatment, the first trial's completers and non-completers presented a comparable clinical state.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Amantadine / administration & dosage*
  • Cocaine-Related Disorders / rehabilitation*
  • Comorbidity
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female
  • Heroin Dependence / rehabilitation*
  • Humans
  • Male
  • Methadone / administration & dosage*
  • Middle Aged
  • Neurologic Examination / drug effects
  • Patient Admission*
  • Substance Withdrawal Syndrome / diagnosis
  • Treatment Outcome


  • Amantadine
  • Methadone