In search of a function for the TIS21/PC3/BTG1/TOB family

FEBS Lett. 2001 May 25;497(2-3):67-72. doi: 10.1016/s0014-5793(01)02436-x.


The Btg family of anti-proliferative gene products includes Pc 3/Tis 21/Btg 2, Btg 1, Tob, Tob2, Ana/Btg3, Pc3k and others. These proteins are characterized by similarities in their amino-terminal region: the Btg1 homology domain. However, the pleiotropic nature of these family proteins has been observed and no common physiological function among family members was suggested from the history of their identification. Recent progress in the search for Btg family functions has come from the analysis of cell regulation and of cell differentiation. It is now emerging that every member of this family has a potential to regulate cell growth. We would like to propose here to use a nomenclature APRO as a new term for the family.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / physiology*
  • Cell Cycle Proteins / physiology
  • Cell Differentiation / physiology
  • Cell Division / physiology
  • Gene Expression Regulation
  • Genes, Tumor Suppressor
  • Humans
  • Immediate-Early Proteins / physiology*
  • Intracellular Signaling Peptides and Proteins*
  • Multigene Family / physiology*
  • Neoplasm Proteins / physiology*
  • Protein Structure, Tertiary
  • Sequence Homology
  • Tumor Suppressor Proteins*


  • Carrier Proteins
  • Cell Cycle Proteins
  • Immediate-Early Proteins
  • Intracellular Signaling Peptides and Proteins
  • Neoplasm Proteins
  • TOB1 protein, human
  • Tumor Suppressor Proteins
  • BTG2 protein, human
  • BTG1 protein, human