Single nucleotide polymorphism in prohibitin 3' untranslated region and breast-cancer susceptibility

Lancet. 2001 May 19;357(9268):1588-9. doi: 10.1016/s0140-6736(00)04747-4.


The RNA encoded by the 3' untranslated region of the prohibitin gene arrests cell proliferation by blocking the transition between the G1 and S phases of the cell cycle. The product of a variant allele (T allele) is inactive. We did a case-control study of prohibitin genotype in 205 women with breast cancer and 1046 healthy controls. The results showed an association between the T allele and breast cancer in women who reported a first-degree relative with the disease (odds ratio 2.5, p=0.005). An even stronger association was found in a subset of women diagnosed at or before age 50 years (4.8, p=0.003). These data suggest that prohibitin genotyping has value in assessing risk of breast cancer in women aged 50 years or younger with at least one first-degree relative with the disease.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Base Sequence
  • Breast Neoplasms / genetics*
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Middle Aged
  • Molecular Sequence Data
  • Odds Ratio
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide*
  • Probability
  • Proteins / genetics*
  • Reference Values
  • Repressor Proteins*
  • Risk Assessment
  • Sensitivity and Specificity


  • Proteins
  • Repressor Proteins
  • prohibitin