The ins and outs of group II introns

Trends Genet. 2001 Jun;17(6):322-31. doi: 10.1016/s0168-9525(01)02324-1.


Group II introns have attracted considerable attention as ribozymes, mobile genetic elements and possible progenitors of nuclear spliceosomal introns. Major advances in understanding their catalytic structure and dispersal strategies have recently come from several model mitochondrial and bacterial self-splicing introns. In Nature, this family of introns shows wide variation in both features and behaviour, and this review includes a focus on the diversity of evolutionary pathways taken.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Evolution*
  • DNA, Bacterial / genetics
  • DNA, Mitochondrial / genetics
  • Genetic Variation*
  • Introns / genetics
  • Introns / physiology*
  • Models, Genetic
  • Nucleic Acid Conformation
  • Open Reading Frames
  • Phylogeny
  • RNA / chemistry
  • RNA / genetics
  • RNA Splicing*


  • DNA, Bacterial
  • DNA, Mitochondrial
  • RNA