The role of linkage studies for common diseases

Curr Opin Genet Dev. 2001 Jun;11(3):264-7. doi: 10.1016/s0959-437x(00)00188-x.


Linkage analysis when applied to common diseases has had limited success in mapping the genes contributing to them. We present a genealogic approach applied to the relatively isolated population of Iceland. We use an affecteds-only, allele-sharing method--which does not specify any particular inheritance model--implemented in the new statistical program, Allegro, which calculates lod scores based on multipoint calculations. We describe how this approach has helped us to map a gene contributing to the common late-onset form of Parkinson's disease to statistical significance.

Publication types

  • Review

MeSH terms

  • Case-Control Studies
  • Disease
  • Genetic Linkage / physiology*
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing
  • Humans
  • Pedigree