Abstract
The acidocalcisome is an electron-dense acidic organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations. Its limiting membrane possesses a number of pumps and exchangers for the uptake and release of these elements. The acidocalcisome does not belong to the endocytic pathway and may represent a branch of the secretory pathway in trypanosomatids and apicomplexan parasites. The acidocalcisome is possibly involved in polyphosphate and cation storage and in adaptation of these microoganisms to environmental stress.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Calcium Signaling
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Calcium-Transporting ATPases / metabolism
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Carrier Proteins / metabolism
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Endocytosis
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Hydrogen-Ion Concentration
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Intracellular Membranes / physiology
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Intracellular Membranes / ultrastructure
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Organelles / physiology*
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Organelles / ultrastructure
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Proton-Translocating ATPases / metabolism
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Trypanosomatina / physiology*
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Trypanosomatina / ultrastructure
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Vacuolar Proton-Translocating ATPases*
Substances
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Carrier Proteins
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Vacuolar Proton-Translocating ATPases
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Proton-Translocating ATPases
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Calcium-Transporting ATPases