Substance p

Int J Biochem Cell Biol. 2001 Jun;33(6):555-76. doi: 10.1016/s1357-2725(01)00031-0.


This article provides a brief overview of the history of substance P from its discovery in the 1930s to the present day. The development of substance P receptor agonists and antagonists, and more recently the employment of transgenic mice, provide a framework to explore the functional role of substance P. Chronic inflammation and pain are associated with a number of diseases, and it has been proposed that substance P, released from primary afferent nerve endings play a role in these conditions. Recent developments with substance P antagonists have demonstrated the importance of substance P in several models of disease that span from asthma to chronic bronchitis; from cystitis, inflammatory bowel disease to migraine; emesis, depression, pain and seizures. Advancements in the knowledge of the role of substance P, its agonists and antagonists could provide clinical solutions for a variety of chronic inflammatory conditions.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Mice
  • Molecular Sequence Data
  • Neurokinin-1 Receptor Antagonists
  • Receptors, Neurokinin-1 / agonists
  • Receptors, Tachykinin / metabolism
  • Substance P / biosynthesis
  • Substance P / metabolism*


  • Neurokinin-1 Receptor Antagonists
  • Receptors, Neurokinin-1
  • Receptors, Tachykinin
  • Substance P