bcl-2 expression in non-Hodgkin's lymphomas is not associated with bcl-2 gene rearrangements

Br J Haematol. 2001 May;113(2):383-90. doi: 10.1046/j.1365-2141.2001.02727.x.


Previous reports have associated bcl-2 gene rearrangements found in non-Hodgkin's lymphomas with an inappropriately elevated bcl-2 expression compared with the mature B-cell stage of development. This study investigates bcl-2 expression in non-Hodgkin's lymphomas (NHL) without bcl-2 gene rearrangements. Molecular analysis in 168 patients with NHL revealed 45 patients without bcl-2 gene rearrangements in which additional immunostaining for bcl-2 protein was possible. An unexpectedly high prevalence (39/45) of bcl-2 expression was found. The levels and patterns of bcl-2 expression were not specific for the histological type of NHL and were similar to those shown in comparable cases with bcl-2 gene rearrangements. In conclusion, bcl-2 expression is not specific for NHL bearing bcl-2 gene rearrangements. This finding implicates the existence of other deregulating control mechanisms of bcl-2 expression, more important than bcl-2 gene rearrangements.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoradiography
  • Chromosomes, Human, Pair 14
  • Chromosomes, Human, Pair 18
  • Gene Expression
  • Gene Rearrangement*
  • Genes, bcl-2*
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Lymphoma, Non-Hodgkin / genetics*
  • Proto-Oncogene Proteins c-bcl-2 / analysis
  • Translocation, Genetic


  • Proto-Oncogene Proteins c-bcl-2