HLA alleles and haplotypes in the Turkish population: relatedness to Kurds, Armenians and other Mediterraneans

Tissue Antigens. 2001 Apr;57(4):308-17. doi: 10.1034/j.1399-0039.2001.057004308.x.

Abstract

Turkish and Kurdish HLA profiles are studied for the first time. The comparative study of their allele frequencies, characteristic haplotypes, genetic distances with other Mediterraneans is complemented by neighbor-joining dendrograms and correspondence analyses. Turks, Kurds, Armenians, Iranians, Jews, Lebanese and other (Eastern and Western) Mediterranean groups seem to share a common ancestry: the older "Mediterranean" substratum. No sign of the postulated Indo-European (Aryan) invasion (1200 B.C.) is detected by our genetic analysis. It is concluded that this invasion, if occurred, had a relatively few invaders in comparison to the already settled populations, i.e. Anatolian Hittite and Hurrian groups (older than 2000 B.C.). These may have given rise to present-day Kurdish, Armenian and Turkish populations.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Armenia
  • Ethnic Groups / genetics*
  • Gene Frequency
  • HLA Antigens / genetics*
  • HLA-A Antigens / genetics
  • HLA-B Antigens / genetics
  • HLA-DQ Antigens / genetics
  • HLA-DR Antigens / genetics
  • Haplotypes / immunology*
  • Humans
  • Mediterranean Region
  • Turkey

Substances

  • HLA Antigens
  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-DQ Antigens
  • HLA-DR Antigens