Trisomy 8 as sole karyotypic aberration in an ovarian metastasizing Sertoli-Leydig cell tumor

Hum Pathol. 2001 May;32(5):559-62. doi: 10.1053/hupa.2001.24316.


Sertoli-Leydig cell tumors (SLCTs) represent a rare group of sex-cord stromal tumors of the ovary of unknown pathogenesis. We report a SLCT of intermediate differentiation with peritoneal recurrence and lymph node metastasis 12 months after removal, including cytogenetic analysis by comparative genomic hybridization and fluorescence in situ hybridization, which showed trisomy 8 as sole unbalanced karyotypic aberration. Our results provide evidence that a simple numeric chromosomal abnormality in SLCT may be associated with a malignant phenotype and suggest that the molecular pathogenesis of SLCT may be different from ovarian granulosa-stromal cell tumors.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Chromosomes, Human, Pair 8*
  • Fatal Outcome
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Lymphatic Metastasis
  • Neoplasm Metastasis / genetics*
  • Neoplasm Recurrence, Local
  • Nucleic Acid Hybridization
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / surgery
  • Peritoneum / pathology
  • Sertoli-Leydig Cell Tumor / genetics*
  • Sertoli-Leydig Cell Tumor / pathology
  • Sertoli-Leydig Cell Tumor / surgery
  • Trisomy*