Spontaneous neoplastic lesions in aged Sprague-Dawley rats

Exp Anim. 2001 Apr;50(2):99-103. doi: 10.1538/expanim.50.99.

Abstract

Neoplastic lesions were observed in untreated aged Sprague Dawley (SD) rats throughout their lifespan starting at 5 weeks. Their mean survival times were 89 to 105 weeks of age. The total tumor incidences were 70 to 76.7% and 87 to 95.8% in males and females, respectively. The common neoplasmas were pituitary adenoma and adrenal pheochromocytoma in both sexes, testicular Leydig cell tumor in males and mammary gland tumors, thyroidal C-cell adenoma and uterine stromal polyp in females.

MeSH terms

  • Adenoma / epidemiology
  • Adenoma / veterinary
  • Adrenal Gland Neoplasms / epidemiology
  • Adrenal Gland Neoplasms / veterinary
  • Aging*
  • Animals
  • Female
  • Leydig Cell Tumor / epidemiology
  • Leydig Cell Tumor / veterinary
  • Male
  • Mammary Neoplasms, Animal / epidemiology
  • Neoplasms / epidemiology
  • Neoplasms / veterinary*
  • Pheochromocytoma / epidemiology
  • Pheochromocytoma / veterinary
  • Pituitary Neoplasms / epidemiology
  • Pituitary Neoplasms / veterinary
  • Polyps / epidemiology
  • Polyps / veterinary
  • Rats
  • Rats, Sprague-Dawley
  • Rodent Diseases / epidemiology*
  • Testicular Neoplasms / epidemiology
  • Testicular Neoplasms / veterinary
  • Thyroid Neoplasms / epidemiology
  • Thyroid Neoplasms / veterinary
  • Uterine Neoplasms / epidemiology
  • Uterine Neoplasms / veterinary