Central representation of the sympathetic nervous system in the cerebral cortex

Brain Res. 2001 Jun 8;903(1-2):117-27. doi: 10.1016/s0006-8993(01)02453-2.


The sympathetic-related regions of the cerebral cortex were identified in rats after pseudorabies virus injections were made in functionally different targets: adrenal gland, stellate ganglion which regulates the heart, or celiac ganglion which innervates the gastrointestinal tract. Extensive transneuronal labeling was found in limbic system areas: (1) extended amygdaloid complex, (2) lateral septum, and (3) infralimbic, insular, and ventromedial temporal cortical regions (viz., ectorhinal cortex=Brodmann's area 36, perirhinal cortex=area 35, lateral entorhinal=area 28, and ventral temporal association cortex=Te3 region). Deep temporal lobe structures were prominently labeled, including the amygdalopiriform and amygdalohippocampal transition areas, ventral hippocampus and ventral subiculum. The cortical circuits mediating emotional-autonomic changes (i.e., mind-body control) are discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amygdala / cytology
  • Animals
  • Cerebral Cortex / cytology*
  • Emotions / physiology
  • Herpesvirus 1, Suid
  • Neural Pathways
  • Parahippocampal Gyrus / cytology
  • Psychophysiologic Disorders / pathology
  • Rats
  • Septum of Brain / cytology
  • Sympathetic Nervous System / cytology*