The receptor for the type I insulin-like growth factor and its ligands regulate multiple cellular functions that impact on metastasis

Surg Oncol Clin N Am. 2001 Apr;10(2):289-312, viii.


The receptor for the type I insulin-like growth factor (IGF-IR) has been identified as a regulator of cellular transformation and the acquisition of the tumorigenic phenotype. This article reviews recent evidence including the authors' own, which implicates this receptor and its ligands IGF-I and IGF-II in the regulation of multiple cellular functions that impact on the invasive/metastatic potential of cancer cells. These include cell survival, motility, invasion, growth potential in secondary organ sites, the induction of angiogenesis, and the acquisition of multiple drug-resistance. Collectively, this evidence identifies the IGF-I receptor/ligand system as a target for molecular anti-cancer therapy with potential benefits for a wide spectrum of human malignancies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Movement / physiology
  • Cell Transformation, Neoplastic*
  • Drug Resistance, Neoplasm
  • Humans
  • Integrins / physiology
  • Neoplasm Invasiveness / physiopathology
  • Neoplasm Metastasis / genetics*
  • Neoplasm Metastasis / physiopathology*
  • Neovascularization, Pathologic / physiopathology
  • Paracrine Communication / physiology
  • Phenotype
  • Receptor Cross-Talk / physiology
  • Receptor, IGF Type 1 / physiology*
  • Signal Transduction / physiology


  • Integrins
  • Receptor, IGF Type 1