The role of matrix metalloproteinases in tumor invasion, metastasis, and angiogenesis

W G Stetler-Stevenson

The role of matrix metalloproteinases in tumor invasion, metastasis, and angiogenesis

Surg Oncol Clin N Am. 2001 Apr;10(2):383-92, x.

Author

W G Stetler-Stevenson¹

Affiliation

¹ Extracellular Matrix Pathology Section, Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, Bethesda, Maryland 20892-1500, USA. sstevenw@mail.nih.gov

PMID: 11382593

Abstract

Tumor invasion and metastasis formation are the hallmarks of malignant cancer. Metastatic spread of cancer cells is a result of a complex cascade of cellular events. This article discusses the matrix metalloproteinase family, the regulation of matrix metalloproteinase activity, and the functions of matrix metalloproteinases in tumor progression.

Publication types

Review

MeSH terms

Disease Progression
Humans
Matrix Metalloproteinases / chemistry
Matrix Metalloproteinases / physiology*
Neoplasm Invasiveness / genetics*
Neoplasm Invasiveness / physiopathology*
Neoplasm Metastasis / genetics*
Neoplasm Metastasis / physiopathology*
Neovascularization, Pathologic / enzymology*

Substances

Matrix Metalloproteinases