The incidence of lymphoid and myeloid malignancies among hospitalized Crohn's disease patients

Inflamm Bowel Dis. 2001 May;7(2):106-12. doi: 10.1097/00054725-200105000-00005.


An association may exist between Crohn's disease (CD) and lymphoid/myeloid malignancies. We aimed to evaluate the 2-year cumulative incidence rate of lymphoid/myeloid malignancy among hospitalized CD patients. This is a retrospective cohort study using hospital discharge data from California and Virginia. Cohorts were defined by the presence or absence of a CD diagnosis in all patients discharged during a single calendar year (Year-2). The presence or absence of lymphoid/myeloid malignancy was determined for all hospitalizations during a 4-year period (Year-1 to Year-4) for each member of both cohorts. To obtain a 2-year cumulative incidence rate, patients with lymphoid/myeloid malignancy prior to or at the time of their first admission in Year-2 were excluded. Patients were followed for 8 quarters after this admission for the incidence of lymphoid/myeloid malignancy. Cumulative incidence rates and odds ratios were calculated. The crude 2-year incidence rate of lymphoid/myeloid malignancy among hospitalized CD patients was 3.87/1.000 CD patients (21/5,426; 95% CI = 2.40-5.92). The odds ratio adjusted for age, gender, and race was 2.04 (95% CI = 1.33-3.14, p < 0.001). The 2-year cumulative incidence of lymphoid/myeloid malignancies among hospitalized CD patients is greater than that seen in hospitalized patients without CD. This finding supports the need for further prospective population-based studies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Cohort Studies
  • Crohn Disease / complications*
  • Crohn Disease / epidemiology
  • Data Interpretation, Statistical
  • Female
  • Hospitalization / statistics & numerical data
  • Humans
  • Leukemia / complications*
  • Leukemia / epidemiology
  • Lymphoma / complications*
  • Lymphoma / epidemiology
  • Male
  • Middle Aged
  • Multiple Myeloma / complications*
  • Multiple Myeloma / epidemiology
  • Odds Ratio
  • Retrospective Studies