Transient fetal hypothyroidism due to direct fetal administration of amiodarone for drug resistant fetal tachycardia

Am J Perinatol. 2001;18(2):113-6. doi: 10.1055/s-2001-13637.

Abstract

Amiodarone, an anti-arrhythmic drug that contains 39% iodine, is rarely known to cause negative effects on fetal thyroid function after gestational exposure, when given orally to a pregnant woman. Two cases of fetal hypothyroidism after gestational exposure to amiodarone by direct fetal intravenous route are described here.

MeSH terms

  • Adult
  • Amiodarone / administration & dosage
  • Amiodarone / adverse effects*
  • Amiodarone / therapeutic use
  • Anti-Arrhythmia Agents / administration & dosage
  • Anti-Arrhythmia Agents / adverse effects*
  • Anti-Arrhythmia Agents / therapeutic use
  • Female
  • Fetal Diseases / chemically induced*
  • Fetal Diseases / drug therapy*
  • Humans
  • Hypothyroidism / chemically induced*
  • Hypothyroidism / drug therapy
  • Infant, Newborn
  • Injections, Intravenous
  • Male
  • Pregnancy
  • Tachycardia, Supraventricular / drug therapy*
  • Thyroxine / therapeutic use
  • Time Factors

Substances

  • Anti-Arrhythmia Agents
  • Amiodarone
  • Thyroxine