Expanding drug resistance through integron acquisition by IncFI plasmids of Salmonella enterica Typhimurium

Emerg Infect Dis. May-Jun 2001;7(3):444-7. doi: 10.3201/eid0703.010314.


We conducted a 30-year retrospective analysis of IncFI plasmids from Salmonella enterica serotype Typhimurium. These plasmids have been associated with the emergence of epidemic clones of multidrug-resistant Salmonella. Molecular and genetic evidence indicates that IncFI plasmids are evolving through sequential acquisition of integrons carrying different arrays of antibiotic- resistance genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Resistance, Microbial
  • Plasmids*
  • Retrospective Studies
  • Salmonella typhimurium / drug effects*
  • Salmonella typhimurium / genetics*