Coronary artery disease but not coronary calcification is associated with elevated levels of cardiolipin, beta-2-glycoprotein-I, and oxidized LDL antibodies

Cardiology. 2001;95(1):20-4. doi: 10.1159/000047338.


Background: Autoimmune factors have been shown to play a role in atherosclerosis. The aim of this study is to correlate 5 autoantibodies (anticardiolipin, anti-CL, beta2-glycoprotein-I, beta2GPI, phosphatidylcholine, oxidized low-density lipoprotein, oxLDL, endothelial cell) with the presence of coronary heart disease, angiographic findings, and with coronary artery calcification.

Methods: The levels of the 5 autoantibodies and a control antifibroblast line of 126 coronary heart disease patients and 20 healthy controls were measured. Fifty-one patients underwent coronary angiography, and 98 patients had coronary artery calcium determination using spiral computerized tomography (dual mode).

Results: Levels of 3 autoantibodies (anti-CL, beta2GPI, oxLDL) were significantly elevated in coronary heart disease patients compared with controls (p < 0.001, p = 0.001, p < 0.001, respectively). Within the subgroup of patients with significant coronary artery stenosis, anti-CL antibodies were also elevated (p = 0.008). No correlation was found between anti-CL, and anti-beta2GPI autoantibody levels and coronary calcium scores as measured by spiral computerized tomography. However, anti-oxLDL antibodies were raised in patients with no calcification detected by spiral computerized tomography, compared with the patients with any coronary calcification (p = 0.046).

Conclusion: Anti-CL, beta2GPI and oxLDL antibodies are elevated in coronary heart disease patients regardless of coronary calcification.

MeSH terms

  • Aged
  • Autoantibodies / blood*
  • Biomarkers / blood
  • Calcinosis / complications
  • Cardiolipins / immunology*
  • Case-Control Studies
  • Cholesterol, LDL / immunology*
  • Coronary Disease / blood
  • Coronary Disease / etiology*
  • Female
  • Glycoproteins / immunology*
  • Humans
  • Male
  • Tomography, X-Ray Computed
  • beta 2-Glycoprotein I


  • Autoantibodies
  • Biomarkers
  • Cardiolipins
  • Cholesterol, LDL
  • Glycoproteins
  • beta 2-Glycoprotein I