The allogeneic response and tumor immunity

Nat Med. 2001 Jun;7(6):649-52. doi: 10.1038/89008.


The strong allogeneic response to donor MHC molecules in transplantation and the weak response to tumor antigens represent two important and divergent but potentially interactive immune responses. A patient's response to allogeneic MHC molecules might promote an effective T-cell response to self MHC-restricted tumor peptides and the possibilities for this are discussed here. These allogeneic responses might successfully be harnessed to promote the immune eradication of metastatic cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • HLA Antigens / immunology
  • Humans
  • Immunotherapy*
  • Isoantigens / immunology*
  • Major Histocompatibility Complex / immunology*
  • Neoplasms / immunology*
  • Neoplasms / physiopathology
  • Peptides / immunology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / physiology
  • Transplantation, Homologous


  • HLA Antigens
  • Isoantigens
  • Peptides