Application of Low Copy Number DNA Profiling

Croat Med J. 2001 Jun;42(3):229-32.

Abstract

Low copy number (LCN) DNA profiling is a technique sensitive enough to analyze just a few cells. When this kind of analysis is carried out, special considerations are needed to interpret the results. In particular, it is important to consider the implications of allele dropout and the possibility of contamination from a laboratory source. A rationale for interpreting LCN DNA is described.

Publication types

  • Review

MeSH terms

  • DNA Fingerprinting / methods*
  • Forensic Medicine / methods*
  • Gene Amplification
  • Humans
  • Nucleic Acid Amplification Techniques*
  • Polymerase Chain Reaction / methods*
  • Sensitivity and Specificity
  • Tandem Repeat Sequences