Imaging infection with LeuTech

Nucl Med Commun. 2001 May;22(5):513-9. doi: 10.1097/00006231-200105000-00008.


LeuTech is a 99Tcm labelled, anti-CD15, IgM, murine monoclonal antibody shown to have high affinity (Kd = 10(-11) M) for CD15 receptors (5.1 x 10(5)/cell) expressed on human neutrophils. LeuTech was injected directly, intravenously, and its efficacy in imaging infection in 46 consecutive patients was determined. Human anti-mouse antibody (HAMA) response was examined in 30 normal volunteers using a standard LeuTech dose reconstituted with decayed 99Tcm solution. There were 38 true positive, six true negative, and two false negative scans. Of the 38 positive images, 33 (92%) were positive within 10 min after injection of LeuTech. LeuTech accuracy in this group of patients was 96%, sensitivity 95%, specificity 100%, positive predictive value (PPV) 100%, and negative predictive value (NPV) 75%. No elevation of the HAMA titre was observed in any of the 30 normal volunteers and no adverse reaction was noted in any patient. LeuTech is a highly promising agent for rapid imaging of infectious foci.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Animals
  • Antibodies, Monoclonal*
  • Appendicitis / diagnostic imaging
  • Bone Diseases / diagnostic imaging
  • False Negative Reactions
  • Female
  • Humans
  • Infections / diagnostic imaging*
  • Lewis X Antigen / immunology
  • Lung Diseases / diagnostic imaging
  • Male
  • Mice
  • Middle Aged
  • Predictive Value of Tests
  • Radiopharmaceuticals*
  • Reference Values
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tomography, Emission-Computed, Single-Photon


  • Antibodies, Monoclonal
  • Lewis X Antigen
  • Radiopharmaceuticals
  • techneticum TC-99M fanolesomab