Severe reversible renal failure due to naproxen-associated acute interstitial nephritis

Eur J Pediatr. 2001 May;160(5):293-5. doi: 10.1007/s004310100729.


Acute interstitial nephritis is uncommon in children and has very rarely been described with naproxen treatment. We report the occurrence of severe acute renal failure in a 10-year-old girl with juvenile rheumatoid arthritis after 1 month of naproxen therapy. Renal biopsy showed severe acute interstitial nephritis. The patient recovered completely after discontinuation of naproxen and administration of methylprednisolone. A review of the literature regarding non-steroidal anti-inflammatory drug-associated acute interstitial nephritis is provided.

Conclusion: In an era of increasing popularity of non-steroidal anti-inflammatory drugs for use in children, paediatricians should be aware of the potential renal complications of this class of drugs.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Disease
  • Acute Kidney Injury / chemically induced*
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Arthritis, Juvenile / drug therapy
  • Child
  • Female
  • Humans
  • Naproxen / adverse effects*
  • Naproxen / therapeutic use
  • Nephritis, Interstitial / chemically induced*
  • Steroids


  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Steroids
  • Naproxen