A new technique to elevate night time growth hormone release and a potential growth hormone feedback control loop

Med Hypotheses. 2001 May;56(5):610-3. doi: 10.1054/mehy.2000.1161.

Abstract

A new technique for controllable elevation of night time growth hormone (GH) release in adult humans involves a synergy between oral intake of the naturally occurring compounds acetyl-L-carnitine (500 mg) and L-ornithine (25-100 mg) taken at night time sleep after a 3 to 4 hour fast. The set point for normal hypothalamic GH release appears to include a 'whole body' mitochondrial State 3 status 'feed back loop' controlled by systemic acetyl- L-carnitine levels.

MeSH terms

  • Acetylcarnitine / administration & dosage*
  • Acetylcarnitine / pharmacology
  • Adult
  • Aged
  • Aged, 80 and over
  • Circadian Rhythm*
  • Feedback*
  • Female
  • Growth Hormone / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Ornithine / administration & dosage*
  • Ornithine / pharmacology
  • Sleep / drug effects

Substances

  • Acetylcarnitine
  • Growth Hormone
  • Ornithine