Monitoring solid-phase glycoside synthesis with (19)F NMR spectroscopy

M Mogemark; M Elofsson; J Kihlberg

doi:10.1021/ol015759+

Monitoring solid-phase glycoside synthesis with (19)F NMR spectroscopy

Org Lett. 2001 May 17;3(10):1463-6. doi: 10.1021/ol015759+.

Authors

M Mogemark¹, M Elofsson, J Kihlberg

Affiliation

¹ Organic Chemistry, Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden.

PMID: 11388842
DOI: 10.1021/ol015759+

Abstract

[structure: see text] A simple and efficient method for monitoring and optimizing carbohydrate synthesis on polymeric support by using (19)F NMR spectroscopy is described. The method relies on the use of fluorinated variants of protective groups that are in common use in oligosaccharide synthesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Combinatorial Chemistry Techniques*
Fluorine
Glycosides / chemical synthesis
Glycosides / chemistry*
Nuclear Magnetic Resonance, Biomolecular / methods*
Oligosaccharides / chemical synthesis
Oligosaccharides / chemistry

Substances

Glycosides
Oligosaccharides
Fluorine