Distribution of resistance genes tet(M), aph3'-III, catpC194 and the integrase gene of Tn1545 in clinical Streptococcus pneumoniae harbouring erm(B) and mef(A) genes in Spain

J Antimicrob Chemother. 2001 Jun;47(6):863-6. doi: 10.1093/jac/47.6.863.


The most prevalent macrolide resistance phenotype and genotype among pneumococcal isolates was the cMLSB phenotype [erm(B) or erm(B)/mef(A)] (91.3%). We studied the distribution of other resistance genes, tet(M), catpC194, aph3'-III, in these strains, seeing evolution at work in that some strains carried different combinations of resistance determinants. The most prevalent patterns associated with resistance to erythromycin [erm(B)] were resistance to tetracycline [tet(M)] and chloramphenicol (catpC194) (48.2%) or resistance to tetracycline [tet(M)] alone (42.2%). In our isolates of Streptococcus pneumoniae there was a strong association of the erm(B) and tet(M) genes with Tn1545-related elements.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics*
  • Chloramphenicol Resistance / genetics
  • Conjugation, Genetic / genetics
  • DNA Transposable Elements / genetics*
  • Drug Resistance, Microbial / genetics
  • Humans
  • Integrases / genetics*
  • Kanamycin Kinase / genetics*
  • Macrolides
  • Membrane Proteins / metabolism
  • Methyltransferases / metabolism
  • Microbial Sensitivity Tests
  • Spain
  • Streptococcus pneumoniae / drug effects
  • Streptococcus pneumoniae / enzymology
  • Streptococcus pneumoniae / genetics*


  • Anti-Bacterial Agents
  • Bacterial Proteins
  • DNA Transposable Elements
  • Macrolides
  • MefA protein, Streptococcus
  • Membrane Proteins
  • Tet M resistance protein, Bacteria
  • Methyltransferases
  • rRNA (adenosine-O-2'-)methyltransferase
  • Kanamycin Kinase
  • Integrases