Haemoglobin F Victoria Jubilee (alpha 2 A gamma 2 80 Asp-Try)

Biochim Biophys Acta. 1975 May 30;393(1):188-94. doi: 10.1016/0005-2795(75)90230-5.

Abstract

A new A gamma chain haemoglobin variant, haemoglobin F Victoria Jubilee, with an electrophoretic mobility slightly anodal to haemoglobin F Port Royal, was found in a Jamaican infant. The amino acid residue substitution of 80 Aspartic Acid leads to Tyrosine was associated with alanine in position 136. Haemoglobin F Victoria Jubilee constituted about 7.0 percent of the total haemoglobin F.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Amino Acids / analysis
  • Aspartic Acid / analysis
  • Chromatography, Ion Exchange
  • Electrophoresis, Starch Gel
  • Female
  • Hemoglobins
  • Hemoglobins, Abnormal*
  • Humans
  • Infant, Newborn
  • Jamaica
  • Pedigree
  • Peptide Fragments / analysis
  • Trypsin
  • Tyrosine / analysis

Substances

  • Amino Acids
  • Hemoglobins
  • Hemoglobins, Abnormal
  • Peptide Fragments
  • Aspartic Acid
  • Tyrosine
  • Trypsin