Living dangerously: how Helicobacter pylori survives in the human stomach

Nat Rev Mol Cell Biol. 2001 Jun;2(6):457-66. doi: 10.1038/35073084.


Helicobacter pylori was already present in the stomach of primitive humans as they left Africa and spread through the world. Today, it still chronically infects more than 50% of the human population, causing, in some cases, severe diseases such as peptic ulcers and stomach cancer. To succeed in these long-term associations, H. pylori has developed a unique set of virulence factors, which allow survival in a unique and hostile ecological niche--the human stomach.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Helicobacter Infections / microbiology*
  • Helicobacter Infections / physiopathology*
  • Helicobacter pylori / physiology*
  • Humans
  • Stomach / microbiology
  • Stomach / physiopathology
  • Stomach Diseases / etiology
  • Stomach Diseases / microbiology*
  • Stomach Diseases / physiopathology