Primate anterior cingulate cortex: where motor control, drive and cognition interface

Nat Rev Neurosci. 2001 Jun;2(6):417-24. doi: 10.1038/35077500.


Controversy surrounds the function of the anterior cingulate cortex. Recent discussions about its role in behavioural control have centred on three main issues: its involvement in motor control, its proposed role in cognition and its relationship with the arousal/drive state of the organism. I argue that the overlap of these three domains is key to distinguishing the anterior cingulate cortex from other frontal regions, placing it in a unique position to translate intentions to actions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arousal / physiology
  • Brain Injuries / pathology
  • Brain Injuries / physiopathology
  • Cognition / physiology*
  • Drive*
  • Gyrus Cinguli / anatomy & histology
  • Gyrus Cinguli / physiology*
  • Humans
  • Movement / physiology*
  • Primates / anatomy & histology
  • Primates / physiology
  • Volition / physiology