Antimicrobial Resistance Among Uropathogens That Cause Community-Acquired Urinary Tract Infections in Women: A Nationwide Analysis

Clin Infect Dis. 2001 Jul 1;33(1):89-94. doi: 10.1086/320880. Epub 2001 Jun 5.


Current recommendations for empirical therapy for community-acquired urinary tract infection (UTI) in women hinge on knowledge of antimicrobial susceptibility patterns in the geographic region of the practitioner. We conducted a survey of antimicrobial susceptibilities of 103,223 isolates recovered from urine samples that were obtained in 1998 from female outpatients nationally and within 9 geographic regions in the United States. Resistance of Escherichia coli isolates to trimethoprim-sulfamethoxazole varied significantly according to geographic region, ranging from a high of 22% in the western United States to a low of 10% in the Northeast (P<.001). There were no clinically significant age-related differences in the susceptibility of E. coli to any of the study drugs, but the susceptibility to fluoroquinolones of non-E. coli isolates that were recovered from women who were aged >50 years was significantly lower than that of isolates recovered from younger women (P<.001). The in vitro susceptibility of uropathogens in female outpatients varies according to age and geographic region.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / drug effects*
  • Bacterial Infections / epidemiology
  • Bacterial Infections / microbiology*
  • Community-Acquired Infections / epidemiology
  • Community-Acquired Infections / microbiology*
  • Drug Resistance, Microbial
  • Female
  • Humans
  • Microbial Sensitivity Tests
  • Middle Aged
  • Population Surveillance*
  • United States / epidemiology
  • Urinary Tract Infections / epidemiology
  • Urinary Tract Infections / microbiology*


  • Anti-Bacterial Agents