Short-course therapy for right-side endocarditis due to Staphylococcus aureus in drug abusers: cloxacillin versus glycopeptides in combination with gentamicin

Clin Infect Dis. 2001 Jul 1;33(1):120-5. doi: 10.1086/320869. Epub 2001 Jun 5.


A prospective, randomized clinical trial among drug abusers was conducted to assess the efficacy and safety of a short course of a combination of a glycopeptide (vancomycin or teicoplanin) and gentamicin compared with a combination of cloxacillin and gentamicin for treatment of right-side endocarditis caused by Staphylococcus aureus. Therapeutic success was significantly more frequent with cloxacillin than with a glycopeptide. No adverse effects were noted among patients in the cloxacillin group. A 14-day course of vancomycin or teicoplanin plus gentamicin is ineffective in this instance because it is associated with a high rate of clinical and microbiological failure.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Cloxacillin / therapeutic use
  • Drug Therapy, Combination / therapeutic use*
  • Endocarditis, Bacterial / complications
  • Endocarditis, Bacterial / drug therapy*
  • Endocarditis, Bacterial / microbiology
  • Female
  • Gentamicins / therapeutic use
  • Glycopeptides
  • Humans
  • Male
  • Prospective Studies
  • Staphylococcal Infections / complications
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus*
  • Substance Abuse, Intravenous / complications*
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Gentamicins
  • Glycopeptides
  • Cloxacillin