Identification of a MADS-box gene, FLOWERING LOCUS M, that represses flowering

Plant J. 2001 Apr;26(2):229-36. doi: 10.1046/j.1365-313x.2001.01024.x.


The timing of flowering is important for the reproductive success of plants. Here we describe the identification and characterization of a new MADS-box gene, FLOWERING LOCUS M (FLM), which is involved in the transition from vegetative to reproductive development. FLM is similar in amino-acid sequence to FLC, another MADS-box gene involved in flowering-time control. flm mutants are early flowering in both inductive and non-inductive photoperiods, and flowering time is sensitive to FLM dosage. FLM overexpression produces late-flowering plants. Thus FLM acts as an inhibitor of flowering. FLM is expressed in areas of cell division such as root and shoot apical regions and leaf primordia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • DNA, Plant
  • DNA-Binding Proteins / classification
  • DNA-Binding Proteins / genetics*
  • Gene Expression Regulation, Plant
  • Genes, Plant
  • MADS Domain Proteins
  • Molecular Sequence Data
  • Mutation
  • Phenotype
  • Photoperiod
  • Plant Development
  • Plant Proteins
  • Plant Roots / genetics
  • Plant Stems / genetics
  • Plants / genetics*
  • Plants, Genetically Modified
  • RNA Splicing
  • RNA, Plant
  • Reproduction / genetics
  • Time Factors
  • Transcription Factors / classification
  • Transcription Factors / genetics*


  • DNA, Plant
  • DNA-Binding Proteins
  • MADS Domain Proteins
  • Plant Proteins
  • RNA, Plant
  • Transcription Factors

Associated data

  • GENBANK/AB013395
  • GENBANK/AB019236
  • GENBANK/AB026633
  • GENBANK/AC002291