The use of hormone replacement therapy in postmenopausal women with type 2 diabetes

J Womens Health Gend Based Med. 2001 Apr;10(3):241-55. doi: 10.1089/152460901300139998.


In healthy postmenopausal women, estrogen or hormone replacement therapy (ERT or HRT) can alleviate menopausal symptoms and prevent osteoporosis and may also protect against cardiovascular disease (CVD). In addition to improving lipid metabolism, there are reports that estrogen also improves parameters regulating carbohydrate metabolism, including insulin resistance, in healthy women. Therefore, it is likely that ERT or HRT would also benefit women with type 2 diabetes, not only in relieving menopausal symptoms but also in improving the metabolic abnormalities associated with diabetes and in preventing cardiovascular disease.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / prevention & control
  • Diabetes Mellitus, Type 2 / metabolism*
  • Drug Monitoring
  • Estrogen Replacement Therapy* / adverse effects
  • Estrogen Replacement Therapy* / methods
  • Evidence-Based Medicine
  • Female
  • Humans
  • Hypertriglyceridemia / chemically induced
  • Hypertriglyceridemia / prevention & control
  • Insulin Resistance
  • Osteoporosis, Postmenopausal / prevention & control
  • Patient Selection
  • Postmenopause / drug effects*
  • Postmenopause / physiology*
  • Risk Factors
  • Treatment Outcome
  • Women's Health*