Central Neuronal Histamine Contributes to Cardiovascular Regulation

News Physiol Sci. 1999 Jun:14:100-105. doi: 10.1152/physiologyonline.1999.14.3.100.


Evidence suggests that central histaminergic neurons make important contributions to cardiovascular regulation. For example, histamine-containing neurons project to brain regions important for cardiovascular regulation. Furthermore, stimulation of central histamine receptors changes blood pressure and heart rate and alters activity of major vasoconstrictor systems. Finally, histamine metabolism is changed in hypertension.