Stimulatory and Inhibitory Functions of the R Domain on CFTR Chloride Channel

News Physiol Sci. 2000 Jun;15:154-158. doi: 10.1152/physiologyonline.2000.15.3.154.


CFTR is a chloride channel whose gating process involves coordinated interactions among the regulatory (R) domain and the nucleotide-binding folds (NBFs). Protein kinase A phosphorylation of serine residues renders the R domain from inhibitory to stimulatory and enables ATP binding and hydrolysis at the NBFs, which in turn control opening and closing of the chloride channel.