Detection of the acute phase of abdominal angiostrongyliasis with a parasite-specific IgG enzyme linked immunosorbent assay

Mem Inst Oswaldo Cruz. 2001 May;96(4):515-8. doi: 10.1590/s0074-02762001000400012.

Abstract

Angiostrongylus costaricensis may cause intestinal lesions of varied severity when it accidentally infects man in Central and South America. First-stage larvae have never been detected in stools. Therefore, a parasite-specific IgG ELISA was evaluated for the determination of the acute phase of infection. The specificity and the sensitivity of the immunoassay was shown to be 76.2% and 91.1%, respectively. Eight serum samples taken from patients with histopathological diagnosis, at different time points (3 to 15 months) after surgical treatment, showed a sharp and early decline in antibody reactivity. The titration of anti-A. costaricensis antibodies has proved to be a useful method for the diagnosis of acute abdominal angiostrongyliasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Animals
  • Antibodies, Helminth / analysis*
  • Antibodies, Helminth / blood
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Immunoglobulin G / analysis*
  • Immunoglobulin G / blood
  • Intestinal Diseases, Parasitic / diagnosis*
  • Intestinal Diseases, Parasitic / immunology
  • Sensitivity and Specificity
  • Strongylida Infections / diagnosis*
  • Strongylida Infections / immunology

Substances

  • Antibodies, Helminth
  • Immunoglobulin G