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. 2001 Jun 15;20(11):1563-74.
doi: 10.1002/sim.789.

Incremental Net Benefit in Randomized Clinical Trials


Incremental Net Benefit in Randomized Clinical Trials

A R Willan et al. Stat Med. .


There are three approaches to health economic evaluation for comparing two therapies. These are (i) cost minimization, in which one assumes or observes no difference in effectiveness, (ii) incremental cost-effectiveness, and (iii) incremental net benefit. The latter can be expressed either in units of effectiveness or costs. When analysing data from a clinical trial, expressing incremental net benefit in units of cost allows the investigator to examine all three approaches in a single graph, complete with the corresponding statistical inferences. Furthermore, if costs and effectiveness are not censored, this can be achieved using common two-sample statistical procedures. The above will be illustrated using two examples, one with censoring and one without.

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